Trace mineral metabolism in the avian embryo

USDA, Growth Biology Laboratory, Beltsville, Maryland 20705-2350, USA.

Trace mineral metabolism in the developing avian embryo begins with the formation of the egg and the trace mineral stores contained within it. Vitellogenin, the yolk precursor protein, serves as a trace mineral transporting protein that mediates the transfer of these essential nutrients from stores within the liver of the hen to the ovary and developing oocyte, and hence, to the yolk of the egg. Lipovitellin and phosvitin, derived from intraoocytic proteolytic processing of vitellogenin, are also trace mineral binding proteins that form important storage sites within the granule subfraction of yolk. The mobilization and uptake of egg trace mineral stores is mediated by the extra-embryonic membranes, principally the yolk sac membrane. The yolk sac also serves as a short-term storage site for trace minerals. Because it is an important site of plasma protein synthesis, the yolk sac has the ability to regulate the export of trace minerals to the embryo during development. Within the embryo, specific metaloproteins function in the interorgan transport cellular uptake, and intracellular storage of trace minerals. Thus, embryonic trace mineral homeostasis is established through the coordinated actions of the yolk sac, which mobilizes and exports trace minerals derived from egg stores; the vitelline circulation, which transports them to the embryo; and the liver, which accumulates trace minerals and distributes them to the rest of the tissues of the embryo via the embryonic circulation.

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