Poult. Sci.
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Poultry Science, Vol 79, Issue 7, 1005-1008
Copyright © 2000 by Poultry Science Association

Articles

Perspectives on osteoblast and osteoclast function

CV Gay, VR Gilman, and T Sugiyama

Department of Poultry Science, The Pennsylvania State University, University Park 16802-3501, USA. cvg1@psu.edu

We present evidence that the polar, matrix-forming osteoblasts are connected laterally to form an impervious layer of cells. Next, the possible mechanisms by which calcium ions are translocated across the layer of cells into sites of mineralization are analyzed. Finally, mechanisms of attachment of bone-resorbing osteoclasts are considered. Osteoclasts adhere to matrix, in part, though an arginine-glycine-aspartic acid (RGD)-dependent mechanism. Adherence is under control of parathyroid hormone and 17beta-estradiol.




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