Poult. Sci.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ashwell, C.
Right arrow Articles by McMurtry, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ashwell, C.
Right arrow Articles by McMurtry, J.
Poultry Science, Vol 82, Issue 1, 106-110
Copyright © 2003 by Poultry Science Association

Articles

Hypoglycemia and reduced feed intake in broiler chickens treated with metformin

CM Ashwell and JP McMurtry

Growth Biology Laboratory, USDA-ARS, 10300 Baltimore Ave., Beltsville, Maryland 20705, USA. cashwell@anri.barc.usda.gov

The bi-guanide metformin is used to treat noninsulin dependent diabetes in obese patients. In addition to having antihyperglycemic effects, metformin is also anorectic and reduces BW. These studies were performed to determine if metformin possesses similar properties in chickens. Metformin-HCl was administered to 14-day-old broiler chickens at either 300 or 600 mg/kg per day in the drinking water for 10 d while monitoring BW and feed intake. No changes in water intake were observed, while feed intake and daily gains were only significantly reduced by the 600 mg/kg dose. After oral administration of a single dose of 300 mg/kg metformin-HCl, feed intake was significantly reduced by 4 h and remained suppressed for greater than 24 h relative to controls. Plasma hormones and metabolites (glucose, lactate, insulin, glucagon, uric acid, nonesterified fatty acid, and triglycerides) were monitored at 1, 2, 3, 6, and 24 h posttreatment. Significant and acute decreases in blood glucose, insulin, and triglycerides were observed at 3 h posttreatment as compared to controls. Opposing acute increases in glucagon and NEFA levels were also observed at 3 h followed by an increase in uric add 6 h posttreatment. These observations suggest that metformin induces metabolic changes in birds, similar to that observed in mammals and may act in a common manner. Metformin-HCl may be useful in glucose metabolism studies by inducing hypoglycemia, a condition rarely observed in birds.


This article has been cited by other articles:


Home page
 Poult. Sci.Home page
C. G. Scanes
Perspectives on Analytical Techniques and Standardization
Poult. Sci., November 1, 2008; 87(11): 2175 - 2177.
[Full Text] [PDF]

Home page
 Poult. Sci.Home page
H. Zhou, C. M. Evock-Clover, J. P. McMurtry, C. M. Ashwell, and S. J. Lamont
Genome-Wide Linkage Analysis to Identify Chromosomal Regions Affecting Phenotypic Traits in the Chicken. IV. Metabolic Traits
Poult. Sci., February 1, 2007; 86(2): 267 - 276.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. Chau-Van, M. Gamba, R. Salvi, R. C. Gaillard, and F. P. Pralong
Metformin Inhibits Adenosine 5'-Monophosphate-Activated Kinase Activation and Prevents Increases in Neuropeptide Y Expression in Cultured Hypothalamic Neurons
Endocrinology, February 1, 2007; 148(2): 507 - 511.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the Poultry Science Association.