Effects of lysine deficiencies on plasma levels of thyroid hormones, insulin-like growth factors I and II, liver and body weights, and feed intake in growing chickens

Department of Animal Science, 207 Terrill Hall, 570 Main Street, University of Vermont, Burlington Vermont 05405, USA. lyndon.carew@uvm.edu

Adequate (1.10%) and deficient (0.88, 0.66, and 0.53%) levels of Lys were fed to broiler chicks from 9 to 23 d of age. Groups fed the control diet (1.10% Lys) were also pair-fed daily with each deficient group. Compared with the free-fed control, graded decreases in feed intake occurred as the deficiency worsened, and these were significantly different with 0.66 and 0.53% Lys. Growth decreased significantly with each deficient level of Lys compared with the free-fed control and was always significantly lower than in the pair-fed control groups in each set. Plasma triiodothyronine (T3) was elevated in chicks fed 0.88 and 0.66% lysine but not with 0.53% when compared with the full-fed control treatment. However, in deficient chicks receiving 0.66 and 0.53% Lys, T3 levels were significantly higher compared with their pair-fed controls. Plasma T4 was not significantly different between any treatments. Liver weights decreased significantly at each level of Lys deficiency, but most of the differences disappeared when expressed relative to body weight. Plasma insulin-like growth factor (IGF)-I decreased significantly with the most severe Lys deficiency. However, it decreased to a similar degree in the pair-fed controls, showing that this effect was primarily due to the lower feed intake. Plasma IGF-II levels did not differ between any treatments. No correlations were evident between thyroid hormones and IGF-I or IGF-II values. We concluded that the primary effect of Lys deficiency was an elevation in plasma T3 levels without accompanying changes in plasma T4. No effect of the Lys deficiency per se on plasma IGF-I and IGF-II and liver weights relative to body weights was found.

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