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Candidate Gene Expression Analysis of Toxin-Induced Dilated Cardiomyopathy in the Turkey (Meleagris gallopavo)

K.-C. Lin^*, K. Gyenai^*, R. L. Pyle, T. Geng^*, J. Xu^* and E. J. Smith¹

^* Department of Animal and Poultry Sciences, and Department of Small Animal Clinical Sciences, Virginia Tech, Blacksburg 24061

¹ Corresponding author: esmith{at}vt.edu

Dilated cardiomyopathy (DCM), a heart disease, affects many vertebrates including humans and poultry. The disease can be either idiopathic (IDCM) or toxin-induced (TIDCM). Although genetic and other studies of IDCM are extensive, the specific etiology of TIDCM is still unknown. In this study, we compared mRNA levels of cardiac troponin T (cTnT) and phospholamban (PLN) in turkeys affected and unaffected by TIDCM. Cardiac TnT and PLN were chosen because their altered expression has been observed in IDCM-affected birds. A total of 72 birds, 44 affected and 28 unaffected with TIDCM, were used. Differences in the mRNA levels of cTnT and PLN between affected and unaffected turkeys were significant only for cTnT. The sequence of the turkey PLN showed significant similarity at the nucleotide level to the reference chicken sequence and to those of other species. In addition to implicating cTnT in TIDCM, the present work describes a partial turkey PLN coding sequence that could be useful for future studies.

Key Words: turkey • cardiomyopathy • cardiac troponin T • phospholamban • reverse transcription-polymerase chain reaction

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