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Evaluation of Models Using Corticosterone and Adrenocorticotropin to Induce Conditions Mimicking Physiological Stress in Commercial Broilers^1,2

W. S. Virden^*, J. P. Thaxton^*, A. Corzo^*, W. A. Dozier, III and M. T. Kidd^*,3

^* Department of Poultry Science, Mississippi State University, Mississippi State 39759-9665; and Agriculture Research Service, USDA, Mississippi State, MS 39762-5367

³ Corresponding author: mkidd{at}poultry.msstate.edu

Three experiments (Exp) were conducted to delineate a suitable model for inducing conditions mimicking physiological stress with minimal bird handling. For Exp 1, Ross x Ross 308 male chicks were fed a control diet or a diet containing 5 mg of corticosterone (CS)/kg from d 1 to 7. For Exp 2, Ross x Ross 508 broilers received 1 of 4 dietary treatments: control; control + 4 IU/kg of BW of adrenocorticotropin (ACTH)/d i.m. from d 21 to 27; control + 8 IU/kg of BW of ACTH/d i.m. from d 21 to 27; or control + 15 mg of CS/kg of diet for 14 d from 21 to 35 d of age. In Exp 3, Ross x Ross 308 broilers were fed high or low nutrient density (ND) from 1 to 41 d of age, and 0 or 20 mg of CS/kg of diet from 18 to 21 d of age. Performance parameters (BW gain, feed intake, feed conversion, and mortality) were measured in all 3 experiments. In Exp 1, CS administration significantly decreased BW gain and decreased feed intake and mortality. In Exp 2, although ACTH injection resulted in significantly depressed performance responses relative to the control, CS administration yielded significantly stronger results. In Exp 3, ND and CS interacted (P = 0.04) to affect feed intake from d 0 to 34. Broilers fed diets containing high ND and CS had higher feed intake than broilers fed low ND and CS. From 0 to 21 and 0 to 42 d, CS decreased feed intake. Increased dietary ND improved BW gain and feed conversion in Exp 3. Also, CS decreased and increased BW gain and feed conversion, respectively, during all periods in Exp 3. Dietary addition of CS negatively impacted performance of broilers, and increasing dietary amino acid density did not ameliorate these effects.

Key Words: broiler • stress • corticosterone • adrenocorticotropin • nutrient density

¹ This is journal article number J-10966 from the Mississippi Agricultural and Forestry Experiment Station supported by MIS-322230.

² Use of trade names in this publication does not imply endorsement by the Mississippi Agricultural and Forestry Experiment Station of the products, nor similar ones not mentioned.