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Genome-Wide Linkage Analysis to Identify Chromosomal Regions Affecting Phenotypic Traits in the Chicken. IV. Metabolic Traits¹

H. Zhou^*,,2, C. M. Evock-Clover, J. P. McMurtry, C. M. Ashwell^,3 and S. J. Lamont^*,4

^* Department of Animal Science, Iowa State University, Ames 50011; Growth Biology Laboratory, Livestock and Poultry Sciences Institute, Agricultural Research Service, USDA, Beltsville, MD 20705; and Department of Poultry Science, Texas A&M University, College Station 77843

⁴ Corresponding author: sjlamont{at}iastate.edu

The current study is a comprehensive genome analysis to detect QTL affecting metabolic traits in chickens. Two unique F₂ crosses generated from a commercial broiler male line and 2 genetically distinct inbred lines (Leghorn and Fayoumi) were used in the present study. The plasma glucagon, insulin, lactate, glucose, tri-iodothyronine, thyroxine, insulin-like growth factor I, and insulin-like growth factor II concentrations at 8 wk were measured in the 2 F₂ crosses. Birds were genotyped for 269 microsatellite markers across the entire genome. The program QTL Express was used for QTL detection. Significance levels were obtained using the permutation test. For the 10 traits, a total of 6 and 9 significant QTL were detected at a 1% chromosome-wise significance level, of which 1 and 6 were significant at the 5% genome-wise level for the broiler-Leghorn cross and broiler-Fayoumi cross, respectively. Most QTL for metabolic traits in the present study were detected in Gga 2, 6, 8, 9, 13, and Z for the broiler-Leghorn cross and Gga 1, 2, 4, 7, 8, 13, 17, and E47 for the broiler-Fayoumi cross. Phenotypic variation for each trait explained by all QTL across genome ranged from 2.73 to 14.08% in the broiler-Leghorn cross and from 6.93 to 21.15% in the broiler-Fayoumi cross. Several positional candidate genes within the QTL region for metabolic traits at the 1% chromosome-wise significance level are biologically associated with the regulation of metabolic pathways of insulin, triiodothyronine, and thyroxine.

Key Words: genome scan • quantitative trait loci • metabolic trait • broiler • inbred line

¹ This is journal paper of the Iowa Agriculture and Home Economics Experiment Station, Ames, project number 6680, was supported by Hatch and State of Iowa funds.

² At Texas A&M University since March 2006.

³ Present address: Department of Poultry Science, North Carolina State University, Raleigh 27695.

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