Poult. Sci.
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Poult Sci 2007. 86:786-789
© 2007 Poultry Science Association
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RAPID COMMUNICATION

Genomic Structure and Diversity of the Chicken Mx Gene1

X. Y. Li, L. J. Qu, Z. C. Hou, J. F. Yao, G. Y. Xu and N. Yang2

Department of Animal Genetics and Breeding, College of Animal Science and Technology, and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100094, China

2 Corresponding author: nyang{at}cau.edu.cn

The Mx protein, which confers resistance to orthomyxovirus, has been detected in several organisms, and one nonsynonymous substitution (S631N) of the chicken Mx protein has been shown to affect resistant activities to the avian influenza virus in vitro. In the current study, the genomic sequence and polymorphism of the chicken Mx gene are reported. The full length of the chicken Mx gene spans about 21 kb, with 13 exons on chromosome 1 of the chicken genome. A total of 237 single nucleotide polymorphisms were found in the chicken Mx gene by comparison among 4 directly sequenced Mx genomic DNA sequences, and the reference sequence was inferred from the chicken genome project. The genomic diversity of the chicken Mx gene showed large variation in different regions, with the highest diversity in the 5' untranslated region and the lowest in the 3' untranslated region. The genomic structure and variation of sequences gathered here will allow an extensive analysis of the gene function with the aim of improving the antiviral resistance activities of chickens.

Key Words: chicken • DNA sequence • genomic structure • Mx gene • variation

1 The genomic sequences for the Mx gene of a Silkie, a White Leghorn, and 2 Rhode Island Red chickens were deposited at GenBank under accession nos. DQ788614 [GenBank] , DQ788615 [GenBank] , DQ788613 [GenBank] , and DQ788616 [GenBank] , respectively.




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C. T. O. Benfield, J. W. Lyall, G. Kochs, and L. S. Tiley
Asparagine 631 Variants of the Chicken Mx Protein Do Not Inhibit Influenza Virus Replication in Primary Chicken Embryo Fibroblasts or In Vitro Surrogate Assays
J. Virol., August 1, 2008; 82(15): 7533 - 7539.
[Abstract] [Full Text] [PDF]


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