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Poult Sci 2007. 86:1090-1099
© 2007 Poultry Science Association
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IMMUNOLOGY, HEALTH, AND DISEASE

Natural Humoral Immune Competence and Survival in Layers

L. Star*,1, K. Frankena{dagger}, B. Kemp*, M. G. B. Nieuwland* and H. K. Parmentier*

* Adaptation Physiology Group, {dagger} Quantitative Veterinary Epidemiology Group, Wageningen Institute of Animal Sciences, Wageningen University, PO Box 338, 6700 AH Wageningen, the Netherlands

1 Corresponding author: laura.star{at}wur.nl

The relation between survival and levels of humoral components of innate (and specific) immune competence of laying hens was investigated in a population of 1,063 laying hens from 12 purebred layer lines. Natural immune competence of the chickens was studied by measuring levels of natural antibodies (NAb) binding to keyhole limpet hemocyanin (KLH) or lipopolysaccharide (LPS), respectively, and hemolytic (classical and alternative) complement activity at 20, 40, and 65 wk of age. In addition, levels of antibodies binding a Newcastle disease vaccine strain as a measure of specific immunity were investigated at 20 wk of age. A distinction could be made between lines showing high or low immune competence with respect to NAb, complement activity, and specific antibodies. Within lines, significant correlations were found for each of the innate parameters among the 3 ages. The innate and specific parameters were, however, not correlated with each other. Based on the limited data set, it was not possible to draw conclusions on line differences for innate or specific immune competence in relation to survival. However, regardless of line, low levels of NAb binding to KLH or high levels of NAb binding to LPS were detected in chickens that did not survive the laying period. The major difference between the responses of NAb binding to KLH or LPS was that the chickens probably did not encounter KLH, which suggests a reflection of the capacity to respond, whereas the chickens most probably did encounter LPS, which suggests a reflection of the active status of the innate humoral immune system. In conclusion, we propose that levels (KLH) and activation (LPS) of components of natural antibodies are indicative for the probability that chickens survive a laying period.

Key Words: natural immunity • natural antibody • hemolytic complement activity • specific antibody • survival rate




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