Poult. Sci.
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Poult Sci 2007. 86:1245-1250
© 2007 Poultry Science Association
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PRODUCTION, MODELING, AND EDUCATION

Role of Interleukin-6 in the Pathogenesis of an Avian Model of Staphylococcus aureus Arthritis

Q. Zhou, C. Q. Gu, X. Y. Hu, D. H. Wang, X. M. Li, S. Q. Zhou and G. F. Cheng1

MOA Key Laboratory Food Safety Evaluation, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, P. R. China, 430070

1 Corresponding author: chengguofu{at}mail.hzau.edu.cn

To evaluate the role of interleukin-6 (IL-6) in arthritis induced by Staphylococcus aureus, a chicken model was developed for study. A total of 120 healthy broilers (8 wk old) were randomly divided into 4 groups. Two groups were injected with 0.35 mL of Staph. aureus (7.1 x 109 cfu/mL) into the right hock joints and the other 2 were injected with 0.35 mL of sterile saline into the same joints. One group of each of the 2 treatment groups was fed levofloxacin at a dose of 5 mg/kg of BW on the third day postinoculation for 4 successive days. Chicken blood samples were obtained on d 0, 1, 4, 7, 14, 21, 28, and 35 postinoculation. Chicken IL-6 (chIL-6) activities and concentrations in serum were quantified by B9 bioassay and human IL-6 ELISA, respectively. The results showed that chIL-6 activities and concentrations were reduced (P < 0.05) in the serum of infected broilers treated with levofloxacin compared with birds injected only with Staph. aureus. Levofloxacin treatment had no effect on IL-6 activities and concentrations in uninfected broilers. There was a strong correlation (r = 0.91) between serum chIL-6 activities by the B9 bioassay and serum IL-6 concentrations determined by the human IL-6 ELISA. We concluded that chIL-6 is involved in the progression of chicken arthritis induced by Staph. aureus, and that it contributes to disease incidence and mortality.

Key Words: interleukin-6 • levofloxacin • broiler • Staphylococcus aureus • arthritis






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