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Ontogeny of Cytokine Gene Expression in the Chicken Spleen

Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada

¹ Corresponding author: shayan{at}uoguelph.ca

Cytokine gene expression in the chicken spleen during embryogenesis and the early posthatch period was investigated in the present study. The constitutive expression of interleukin-4, interleukin-10, interleukin-18, and interferon- genes was detectable as early as embryonic day 12. Expression of cytokine genes was higher in the spleen of posthatch chickens compared with chick embryos. There was a gradual increase in expression of all the cytokine genes in the spleen, which peaked by d 7 posthatch. This expression pattern coincided with the completion of T-cell colonization and structural development of the spleen during the early posthatch period. It is therefore possible that the cytokines examined in the present study are involved in the maturation of colonized T cells and in shaping the spleen microenvironment.

Key Words: cytokine • gene expression • embryo • spleen • chicken