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Using Proteomics to Understand Avian Systems Biology and Infectious Disease¹

^* Department of Animal Science, North Carolina State University, Raleigh 27695-7621

² Corresponding author: hc_liu{at}ncsu.edu

The proteome is defined as the protein complement to the genome. Proteomics is the study of the proteome. Several techniques are frequently used in proteomics; these include 2-hybrid systems, 2-dimensional gel electrophoresis, and mass spectrometry. Systems biology is a scientific approach that takes into account the complex relationships among and between genes and proteins and determines how all of these interactions come together to form a functional organism. Proteomic tools can simultaneously probe the properties of numerous proteins and thus are a great aid to the emerging field of systems biology, in which the functional interactions of numerous proteins are studied instead of studying individual proteins as isolated entities. In the field of avian biology, proteomics has been used to study everything from the development and function of organs and systems to the interactions of infectious agents and the altered states that they induce in their hosts.

Key Words: proteomics • systems biology • infectious disease

¹ Presented as part of the Ancillary Scientists Symposium, Functional Genomics: Building the Bridge between the Genome and Phenome, Poultry Science Association Annual Meeting, Sunday, July 16, 2006.

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