Poult. Sci.
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Poult Sci 2009. 88:2628-2635. doi:10.3382/ps.2009-00258
© 2009 Poultry Science Association
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MOLECULAR, CELLULAR, AND DEVELOPMENTAL BIOLOGY

Liver X receptor {alpha} regulates fatty acid synthase expression in chicken

O. Demeure*,{dagger},{ddagger},1, C. Duby*,{dagger},{ddagger}, C. Desert*,{dagger},{ddagger}, S. Assaf*,{dagger},{ddagger}, D. Hazard*,{dagger},{ddagger}, H. Guillou§ and S. Lagarrigue*,{dagger},{ddagger}

* INRA, UMR 598 Génétique Animale, F-35000 Rennes, France; {dagger} Agrocampus Ouest, UMR 598 Génétique Animale, F-35000 Rennes, France; and {ddagger} IFR 140, Génétique Fonctionnelle Agronomie et Santé, F-35000 Rennes, France § INRA, UR66 Laboratoire de Pharmacologie et Toxicologie, F-31931 Toulouse, France

1 Corresponding author: olivier.demeure{at}rennes.inra.fr

Liver X receptor {alpha} (LXR{alpha}), also referred to as nuclear receptor subfamily 1, group H, member 3 is a member of the nuclear hormone receptor superfamily, and has recently been shown to act as a master transcription factor governing hepatic lipogenesis in mammals. Liver X receptor {alpha} directly regulates both the expression of other lipogenic transcription factors and the expression of lipogenic enzymes, thereby enhancing hepatic fatty acid synthesis (FASN). In birds, like in humans, fatty acid synthesis primarily occurs in the liver. Whether LXR{alpha} is involved in hepatic regulation of lipogenic genes remained to be investigated in this species. Here we show that fatty acid synthase and the expression of other lipogenic genes (sterol regulatory element binding protein 1 and steroyl coenzyme A desaturase 1) are induced in chicken hepatoma cells in response to a pharmacological liver X receptor agonist, T0901317. A detailed analysis of the chicken FASN promoter revealed a functional liver X response element. These data define the chicken FASN gene as a direct target of LXR{alpha} and further expand the role of LXR{alpha} as a regulator of lipid metabolism in this species.

Key Words: nuclear receptor subfamily 1 • group H • member 3 • liver X receptor {alpha} • fatty acid synthase • chicken • lipogenesis






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