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Poult Sci 2009. 88:816-823. doi:10.3382/ps.2008-00528
© 2009 Poultry Science Association
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SYMPOSIA: Landmark Papers Symposium

A landmark contribution to poultry science—Immunological function of the bursa of Fabricius1,2

R. L. Taylor, Jr.*,3 and F. M. McCorkle, Jr.{dagger}

* Department of Animal and Nutritional Sciences, University of New Hampshire, Durham 03824; and {dagger} Department of Biology, Central Michigan University, Mt. Pleasant 48859

3 Corresponding author: bob.taylor{at}unh.edu

The article "The bursa of Fabricius and antibody production" by Bruce Glick, Timothy S. Chang, and R. George Jaap first demonstrated the role of the bursa in immune development. Birds, including chickens, possess a peculiar organ, the bursa of Fabricius. The organ was recognized for more than 300 yr before its function was described in 1956. Discovery of the bursa as an essential component of the immune response began by accident. Removal of the bursa, bursectomy, during the rapid growth period diminished the antibody response to Salmonella. A paper describing this exceptional finding was initially rejected by Science and ultimately published in Poultry Science. This revelation triggered sequential events leading to the understanding of the dichotomy of the immune response. Additional work in multiple laboratories over many years revealed fundamental immune mechanisms attributable to the bursa. Understanding those mechanisms advanced agricultural and biomedical science.

Key Words: bursa • B cell • antibody • lymphoid tissue

1 Presented as part of the Landmark Papers Symposium, July 22, 2008, at the Poultry Science Association meeting, Niagara Falls, Ontario, Canada.

2 This is Scientific Contribution Number 2376 from the New Hampshire Agricultural Experiment Station.






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