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A polymorphism in the 3'-flanking region of insulin-like growth factor binding protein 2 gene associated with abdominal fat in chickens

College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, P. R. China

¹ Corresponding author: lihui{at}neau.edu.cn or lihui645{at}hotmail.com

Insulin-like growth factor binding protein 2 (IGFBP2) is the predominant insulin-like growth factor binding protein in serum of different species. It binds insulin-like growth factors and plays an important role in growth and fat metabolism. The current study was designed to investigate the associations of IGFBP2 gene 3'-flanking region polymorphisms with chicken fatness traits. The random populations (5 distinct populations: Arbor Acres broiler, Hyline Brown layer, Shiqiza, BeijingYou, and Baier), the Northeast Agricultural University broiler lines divergently selected for abdominal fat content (NEAUHLF), and the the Northeast Agricultural University F₂ (NEAU F₂) resource population were used in the current study. Body weight and body composition traits were measured in NEAUHLF and NEAU F₂ populations. A SNP of 1196C > A in the 3'-flanking region of the IGFBP2 gene was detected, and the PCR-single strand conformation polymorphism method was then used to genotype all of the individuals derived from the above populations. There was a highly significant difference (P < 0.01) in the allele frequency among the 5 distinct populations. The IG-FBP2 polymorphism was significantly associated with abdominal fat weight and percentage of abdominal fat (P < 0.05) in NEAUHLF and NEAU F₂ populations. The research suggests that the IGFBP2 gene could be a candidate locus or linked to a major gene that affects fatness traits in chickens.

Key Words: chicken • fatness • insulin-like growth factor binding protein 2 gene • quantitative trait loci